Make Up Your Mind! When Phosphorylation Turns Enzymes “ON” or “OFF”

In his latest BenchFly article, Chris describes how protein phosphorylation differs from the simplistic textbook concepts that we’re often taught. Thinking back to a 2nd year biochemistry course, we can recall examples of how phosphorylation might turn an enzyme on, or turn enzymes off. But what happens in instances where phosphorylation at one site might turn and enzyme on, and yet phosphorylation at another site within the very same enzyme, might turn it off? Take a look at the article here!